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KMID : 0613820100200040602
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Journal of Life Science
2010 Volume.20 No. 4 p.602 ~ p.606
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Matrix Metalloproteinase-3 Gene Polymorph isms (A(-267)G, A658G, T813C) is Associated with Type 2 Diabetes in Koreans
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Yoo Min
Kim Hyo-Jeong
Ye Qing
Kim Jong-Won
Kim Su-Won
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Abstract
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Type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. Proteins in the matrix metalloproteinase-3 (MMP3) family are involved in the breakdown of the extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes. Therefore, we investigated the genotype for the A(-267)G, A658G and T813C polymorphisms in the MMP3 gene in the Korean population and compared genotypes of patients with those of the control group. 200 patients (male 108, female 92), who had previously been diagnosed with type 2 diabetes (T2DM) and 100 control subjects (male 36, female 64) participated in this study. There was a strong association between A(-267)G and A658G polymorphism in the MMP3 gene and T2DM. The present study shows that MMP3 polymorphisms (A(-267)G and A658G) may be associated with the pathogenesis of T2DM. Further studies with a larger population may be needed for the development of diagnostic methods at a genetic level, such as DNA chip.
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KEYWORD
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Type 2 Diabetes, matrix metalloproteinase-3 gene, polymorphism, DNA chip, Korean population
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